The placement of the methyl group between the two carbons so to speak produces a cyclopropyl system. Shulgin lists the dosage range of mmda as 100250 mg. He states that it is essentially inactive at a dose of 70 mg, and he did not try any higher. It is also the n,ndimethyl analog of 3,4methylenedioxyamphetamine mda. This is very much like a slow mda, perhaps 80 milligrams of it, and fully as controllable. It is an analogue of lophophine, mda, and mdma mmda was described by alexander shulgin in his book pihkal.
About this version of pihkal this is an online version of the second half of the book pihkal. The et 2 o insoluble residue finally set up to a pale pink mass which was finely ground under a few ml acetone. However, in a swift reaction to the announcement made by nafdac on methyl bromide ban, the nigeria agricultural quarantine service naqs, an agency under the supervision of the federal ministry of agriculture and rural development, argued that the use of the agrochemical is still permissible for controlled quarantine due to lack of suitable alternatives in nigeria. The product 4bromo2,5dimethoxynmethylamphetamine hydrochloride methyl dob separated as fine white crystals which weighed, after filtering and air drying, 0. Bohd 4 methyl 2,5dimethoxybetahydroxyphenethylamine, is a lesserknown psychedelic drug. There have been many rumors about mda, mdea and mdma, mainly saying that one is harder to make than another. This version of book ii of pihkal is based on the erowid online version, originally transcribed by simson garfinkle and converted into html by lamont granquist. According to shulgins book pihkal 1991, he synthesized mdma in 1965, but did not try it. Mmda was described by alexander shulgin in his book pihkal. Explore the structures and analogues of 2 methyl 4,5methylenedioxyamphetamine, 6 methyl mda, 16 methyl 1,3benzodioxol5ylpropan2amine, 6me mda, 16 methyl 2h1,3benzodioxol5ylpropan2amine, 2me4,5 mda in book ii of tihkal.
The first effects appear within 3060 minutes following oral administration. It is presented with the express permission of the authors in order to spread the factual information as widely as possible and make it permanently available in the public domain. Chemspider 1555 pubchem 1614 wikidata q223020 erowid mda wikipedia 3,4methylenedioxyamphetamine. When i decided to autonode it and make it available here on e2, i realized that fastanddirty cut and paste wouldnt do the trick. The subject of the work is psychoactive phenethylamine chemical derivatives, notably those that act as psychedelics andor empathogenentactogens. Isomerization of safrole is reportedly an easy operation, as described in the famous strike synthesis collection.
The first tells the story of the authors lives and their exposure to pihkal s. In his book pihkal, the dose is listed as 2550 mg, and the duration is listed as 812 hours. Mbdb is a closely related chemical analogue of mdma, with t. The main title, pihkal, is an acronym that stands for phenethylamines i have known and loved. I am afraid to turn around and face the mountains, for fear they will overpower me.
In truth, methyl ma is a well studied drug, at least in animals. The bending of this alpha methyl group back to the aromatic ring gives an aminoindane, and with j one gets an aminotetralin. Pihkal phenethylamines i have known and loved is a unique book written by renowned psychopharmacologist alexander shulgin and his wife ann shulgin. A naturally occurring compound found in both the animal and plant kingdoms. Alexander shulgin was the godfather of ecstasy, playing an instrumental. After being brought back to room temperature, the excess hydride was destroyed with 15 ml ipa, followed by 15 ml of 15% naoh. N methyl 11,3benzodioxol5yl2butanamine as a discriminative stimulus in studies of 3,4methylenedioxymethamphetaminelike behavioral activity.
Metaescaline was first synthesized by alexander shulgin. Top american libraries canadian libraries universal library community texts project gutenberg biodiversity heritage library childrens library. Whether youve loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right for them. In both mice and rats, it is an exceptionally potent agent in creating the state of catatonia.
The 12 most important drugs shulgin designed, synthesised. It not just looks good, but it has reaction overviews drawn with the syntheses, which makes shulgins magic more comprehensible for people somewhere. In his book pihkal, the dosage range is listed as 1520 mg, and the duration is listed as 48 hours. In 1967 while working as a surrogate daddyinresidence for noel chesnuts graduate students at the university of california in san francisco a student approached him named merrie kleinman who relayed to him that her and two friends had experimented with 100mg of nmethylated mda mdma.
A solution of 120 mg mercuric chloride in 160 ml h2o was poured over 4. The continuation is a 1997 book written by alexander shulgin and ann shulgin about a family of psychoactive drugs known as tryptamines. This phenol, on ethylation, gives 2ethoxy5methoxytoluene. If you are seriously interested in the chemistry contained in these files, you should order a copy of the book pihkal. In terms of pharmacology, mda acts most importantly as a serotoninnorepinephrinedopamine releasing agent. According to shulgins book pihkal 1991, he synthesized mdma in. The subject of the work is psychoactive phenethylamine chemical derivatives, notably those that act as psychedelics andor empathogen entactogens.
In his book pihkal, the minimum dosage is listed as 50 mg, and the duration unknown. Synthesis instructions exist which can be followed by an amateur with very little knowledge of chemistry. If you do not have exceptional chemistry experience and lack an appropriate approval from the respective drug enforcement agency in your country, do not follow and apply the methods as outlined here. Metaescaline produces mental insights, entactogenic, mdmalike effects, and tomsolike activation. The 12 most important drugs shulgin designed, synthesised and. This aqueous phase was washed with ch2cl2, made basic with naoh, and extracted with 3x100 ml ch2cl2. The second is more of a chemical reference, detailing in a more scientific method the creation and experiences of each pihkal s. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The two possible homologues, with either one or two methyl groups on the methylene carbon of the methylenedioxy group of mda, are also known. A chemical love story, by alexander shulgin and ann shulgin. Pihkal is the acronym for phenethylamines i have known and loved. The h2o was then drained and the foil washed with 2x200 ml h2o with thorough draining. Alexander shulgin and ann shulgin, published in 1991. The product 4bromo 2,5dimethoxynmethylamphetamine hydrochloride methyldob separated as fine white crystals which weighed, after filtering and air drying, 0.
The phenethylamine that corresponds to mda removing the alphamethyl group is 3. Dmcpa produces openeye visuals, anorexia, and psychedelic dreams. The clear solution slowly deposited white crystals which were removed by filtration and air dried to give 4. It is the nmethylated derivative of mmda2, and is also an analog of mdma and 6 methyl mda. Alexander sasha shulgin gives the definition at the beginning of the book.
Methyl definition is an alkyl radical ch3 derived from methane. Alexander shulgin and ann shulgin about psychedelic. Several years ago, alexander shulgin graciously made the pihkal recipes freely available. It also functions as a 5ht2a, 5ht2b, and 5ht2c receptor agonist and shows affinity for the taar1. The most famous route is probably one of shulgins original synths from pihkal third paragraph, starting with pmk mdp2p made from isosafrole. Metaescaline 3,4dimethoxy5ethoxyphenethylamine is a lesserknown psychedelic drug. A chemical love story, tihkal is an acronym that stands for tryptamines i have known and loved.
Very little data exists about the pharmacological properties, metabolism, and. Many have been explored and, with one exception, the quality and potency of human activity is down. Almost all of them show some hallucinogenic qualities, and many are covered in two books by chemist alexander shulgin. What are you wanting to get out of reading these books.
In the 1960s shulgin also synthesized mdmarelated compounds such as 3,4methylenedioxyamphetamine mda, 3methoxy4,5methylenedioxyamphetamine mmda and 3,4methylenedioxyethylamphetamine mde, but this had no impact on his rediscovery of mdma. It is the nhydroxy homologue of mdma, and the nmethyl homologue of mdoh. There was added, dropwise, 18 g of,4methylenedioxyphenyl2nitropropene in solution in thf and the reaction mixture was maintained at reflux for 36 h. Structure, properties, spectra, suppliers and links for. The et2oinsoluble residue finally set up to a pale pink mass which was finely ground under a few ml acetone. Mdmarelated compounds such as 3,4methylenedioxyamphetamine mda.
Other readers will always be interested in your opinion of the books youve read. Mda the parent compound to which mdma is related, this drug. Shulgin reports that mmda2 produces effects such as enhanced awareness, empathy, and visual facilitation and distortion, as well as some side effects like gastrointestinal upset and appetite loss. The adding of another carbon atom to the alphamethyl group of mda gives compound j, and. This html version of tihkal was created by bo lawler with the help of erowid. Most research chemicals are highly dose sensitive and can produce a wide variety of effects. A suspension of 20 g lah in 250 ml anhydrous thf was placed under an inert atmosphere and stirred magnetically. Lsd, writes the chemist alexander shulgin is an unusually fragile molecule as a salt, in water, cold, and free from air and light exposure, it is stable indefinitely. Methallylescaline is a lesserknown psychedelic drug. And in the next longer group, the 3carbon propyl group on the alphaposition becomes the k family, and the 4carbon butyl group located there, the l family.
The adding of another carbon atom to the alpha methyl group of mda gives compound j, and leads to the rest of the munimetro series k, l etc. In 1991 and 1997, he and his wife ann shulgin compiled the books pihkal and tihkal standing for phenethylamines and tryptamines i have known and loved, from notebooks which extensively described their work and personal experiences with these two classes of psychoactive drugs. Animal studies, prompted by the clandestine synthesis of methyl ma, have shown that there is indeed locomotor stimulation and some central effects, but these effects are somehow. There is a direct and traceable lineage between this, and this moment, which shulgin documented in his book pihkal. This was dissolved in 30 ml ipa, neutralized with about 3 ml concentrated hcl, and diluted with 60 ml anhydrous et2o. The drug is usually taken orally, although other routes such as rectally may also be used. Drugs best online pharmacy online drug store eyanstore. In his book pihkal, the minimum dosage is listed as 9 mg, and the duration unknown. Methylmmda2 was first synthesized by alexander shulgin and was described in his book pihkal. Synthesis of mdma mdma is a semisynthetic compound which can be made relatively easily from available precursors. Methylenedioxycyclopropylmethylamphetamine wikimili, the. Methallylescaline was first synthesized by alexander shulgin.
And one of the major metabolites of it in man is the analogue with a hydroxyl group at the 5position of the molecule. Mddm produces only mild effects that are not well characterized in pihkal. This phenolic amine, 5hydroxy2methoxynmethylamphetamine is just a methyl group away from methyldma. Dropping another carbon atom gives a yet shorter chain no carbons at. These books are pihkal phenethylamines i have known and loved and tihkaltryptamines i have known and loved. This book gives details of their research and investigations into the use of psychedelic drugs for the study of the human mind, and is also a love story. Dec 14, 2014 you can pihkal books through amazon, i promise they are worth a read. Dmcpa, or 4 methyl 2,5methoxyphenylcyclopropylamine, is a lesserknown psychedelic drug and a substituted amphetamine. The placement of the methyl group between the two carbons. Here you can download file shulgin pihkal a chemical love story. And the simplest structural unit of change is a single carbon atom, called the methyl group. In his book pihkal phenethylamines i have known and loved, the dosage range is listed as 160240 mg, and the duration as 35 hours. Please forgive any typos or misprints in this file. You need a lot of chemistry knowledge to understand a lot of it.
A chemical love story by alexander and ann shulgin. With 120mg the woodpile is so beautiful, about all the joy and beauty that i can stand. Each with its methyl and ethyl prefixes, if the nitrogen atoms are substituted with a methyl or and ethyl group. The ethylidene compound the acetaldehyde addition to the catechol group has been encoded as eda, and the acetone isopropylidine addition to the catechol group is called ida. I can read easily, but looking at pictures in most books is relatively meaningless. Mdma, its synthesis and most of its precursors are illegal in most parts of the world. Alexander shulgin and ann shulgin which was published in 1991. In his book pihkal, the dosage range is listed as 4065 mg and the duration is listed as 1216 hours.
When the reaction was complete, it was added to 1 l h2o and made strongly basic with 25% naoh. Shulgin performed seminal work into the descriptive synthesis of many of these compounds. Iris 2methoxy5ethoxy4methylamphetamine is a lesserknown psychedelic drug and a substituted amphetamine. But the one exception, the nmethyl analogue of mda, proved to be the most remarkable mdma. Join our community just now to flow with the file shulgin pihkal a chemical love story and make our shared file collection even more complete and exciting. Distinct destressing effect, to the point where its too much trouble to set out to do anything at all, really.